Genotoxic evaluation of ornidazole and secnidazole in albino mice: an experimental study
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چکیده
منابع مشابه
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15 صفحه اولThe evaluation of genotoxic potential of ornidazole, nitroimidazole, in lymphocyte culture of patients with amebiasis.
The genotoxicity study of ornidazole (ONZ) was carried out on human lymphocyte chromosomes, using sister chromatid exchange (SCE) and micronucleus (MN). Thirty-two patients with Entemoeba histolitica infection who received 1000 mg/day for 10 days were included in this study. SCE and MN were measured before and after therapy. A statistically significant increase was observed in the SCE (P < 0.00...
متن کاملEXPERIMENTAL Trypanosoma Evansi INFECTION IN ALBINO MICE – A HISTOPATHOLOGICAL STUDY
Histopathological changes were studied in Swiss albino mice (N:36) which were challenged with the South Indian local strain of Trypanosoma evansi. Each animal was infected with 5×105 trypanosomes intraperitoneally. The animals were examined daily for development of clinical signs and infection status by wet blood-fi lms made from the tail veins. The infected mice were dull and depressed from tw...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2014
ISSN: 2319-2003
DOI: 10.5455/2319-2003.ijbcp20140217